François Lallemend

Project summary

Sensory neurons

Molecular mechanisms controlling the identity of different sensory neurons and their connections to the spinal cord.

 

One of the fundamental questions in developmental biology is to understand the mechanisms that determine the identity of individual neurons and how these nerve cells establish connections with other cells. Sensory neurons in the peripheral nervous system, which transmit information about a wide range of stimuli to the central nervous system, provide an ideal model for studying the mechanisms that determine how specific types of neurons are generated and how their projections are established.

 

Using state-of-the-art technologies, the project aims to identify key factors that control the molecular, morphological and functional properties of sensory neurons. The project will also be the first to characterise, both anatomically and genetically, the different groups of sensory neurons that connect individual muscles in the forelimb to the central nervous system. This specific neural network reflects the critical role of sensory feedback in coordinating movement.

 

In the long term, these studies will provide insights into the fundamental principles involved in the correct formation of the nervous system. They may also lead to new strategies for developing more effective pain treatments and promoting topographically specific nerve regeneration following spinal cord injury.

 

The ambition is to contribute new knowledge and for the group’s published studies to become important references within the field. Another important aspect of the project is to support the group’s early-career researchers through supervision and opportunities for professional development, enabling them to strengthen their abilities and skills as researchers.