Magda Bienko

Project summary

The spatial organisation of the genome in breast cancer

To fully understand the disease-causing consequences of chromosomal alterations, we need a comprehensive picture of the three-dimensional changes that occur in the genome of cancer cells. Using newly developed methods, Magda Bienko studies how the genome adapts to the dramatic structural changes that occur in breast cancer. This research has the potential to reveal new vulnerabilities common to cancer cells and ultimately lead to new treatment strategies.

 

Most forms of cancer exhibit extensive changes in the number and structure of chromosomes. In breast cancer, chromosomal alterations are a central process that causes abnormal regulation of numerous genes, which in turn can drive tumour development. Regardless of the type of alteration involved, rearrangements within and between chromosomes can have profound effects on the structure of the genome, with extensive consequences for gene expression. A complete understanding of the disease-causing effects of chromosomal alterations therefore requires a comprehensive picture of the three-dimensional changes in the cancer cell genome.

 

Using newly developed sequencing and microscopy methods, Magda Bienko studies how structural changes in chromosomes affect the spatial organisation of the entire genome. The research project aims to create a catalogue of different chromosomal alterations and to focus on local topologies involving the genes most frequently affected in breast cancer. The laboratory’s unique microscopy tools make it possible to visualise structural details directly within cells while simultaneously monitoring their activity.

 

The aim of Magda Bienko’s research project is to understand the principles governing how the genome adapts to the dramatic structural changes that occur in breast cancer. The research may reveal previously unknown vulnerabilities shared by cancer cells and thereby pave the way for new treatment strategies.